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Affected people increasingly rely on others for assistance, often placing a burden on the caregiver; the pressures can include social, psychological, physical, and economic elements. Some treatments involve lifestyle changes, such as avoiding alcohol or muscle relaxants, losing weight, and quitting smoking. Women also metabolise drugs used to treat depression differently to men. Small amounts of clotrimazole may be absorbed systemically following topical and vaginal administration. Management of these symptoms primarily involves ketamine cessation, for which compliance is low. Transgenic rodent models that replicate various aspects of PD have been developed. Mental health is a socially constructed and socially defined concept; that is, different societies, groups, cultures, institutions and professions have very different ways of conceptualizing its nature and causes, determining what is mentally healthy, and deciding what interventions, if any, are appropriate. 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